Association for Molecular Pathology


February 2011, Volume 17, Number 1


Solid Tumors Subdivision Report

George J. Netto, MD

By George J Netto, MD

Greetings and best wishes for a New Year, 2011!

I thank our outgoing Solid Tumors Subdivision Chair, Loren Joseph, for his tireless efforts and contributions during the past year. Just when Loren thought he was done, he was recruited back to serve as the Subdivision representative to the Clinical Practice Committee for the upcoming two years. Please join me in welcoming our new members to the Solid Tumors Subdivision leadership team: Federico Monzon as Chair-Elect; our new representative to the Nominating Committee Antonia Sepulveda and Kathy Mangold as representative to the Training and Education (T&E) Committee.

I am very pleased to report that our Solid Tumor Sessions at the Annual Meeting were very well attended and positively received. Great credits go to the diligent work of all the 2010 Program Committee members under the leadership of Barbara Zehnbauer. The AMP Award for Excellence in Molecular Diagnostics recipient, Patrick Brown, delivered an exciting lecture on “The Dark Matter of Biological Regulation,” followed by an equally educational and inspiring Plenary Session on breast cancer by Stefanie Jeffrey and Joe Gray. The two Workshops presented by Thomas Stricker and Marina Nikiforova addressed cutting-edge tools and targets in breast cancer and glial tumors.

Again, abstract submissions increased in number featuring several excellent posters and platform solid tumor presentations in 2010.

On other topics, in December 2010, the T&E Committee hosted a webinar presented by Jaclyn Biegel from the Children's Hospital of Philadelphia on the “Clinical Utility of High Resolution SNP arrays in Pediatric Oncology.” The webinar was very well received. Two additional webinars are planned for 2011 on the topics of c- kit mutation testing, and molecular testing of lung cancer. Speakers and dates are to be announced. Stay tuned for an excellent review on ALK Rearrangement in Non Small Cell Lung Carcinoma by Marileila Varella-Garcia and Dara Aisner. This is in the process of being posted on our Solid Tumors Subdivision webpage. Stay tuned!

The Clinical Practice Committee (CPC) has finalized a manuscript on “Recommendations on MMR testing.” This effort was coordinated by William Funkhouser and will be submitted to The Journal of Molecular Diagnostics. In addition, the CPC has recently approached the College of American Pathology (CAP) regarding guideline development for KRAS and MSI testing. The CAP has suggested combining both under Guidelines for Molecular Diagnostics of Colorectal Cancer. The project will be reviewed and addressed shortly by the CAP and AMP leadership. Neal Lindeman is involved in these two projects, both in draft stage: (1) a joint venture between AMP, CAP, and IASLC to craft guidelines for molecular characterization of lung adenocarcinomas (EGFR, ALK, KRAS). Joining Neal on this project are fellow AMP members Jan Nowak, Marc Ladanyi, Juan-Sebastian Saldivar, Dhananjay Chitale, and Jeremy Squire, and (2) an AMP-led initiative to address MGMT methylation assays in glioma, whose working group includes AMP members Iris Schrijver, Marina Nikiforova, Matija Snuderl, and Adekunle Adesina.

I wish everyone another SOLID, exciting and productive year with AMP!