Association for Molecular Pathology


Self-Test: AMP Case Report Article in CAP TODAY

Coexisting germline mutations in APC and BRCA2 in a patient with colon cancer

 

  1. Mutations in KRAS are associated with:
    a) resistance to EGFR tyrosine kinase inhibitors and monoclonal antibodies
    b) enhanced response to EGFR tyrosine kinase inhibitors and monoclonal antibodies
    c) no impact on response to EGFR tyrosine kinase inhibitors and monoclonal antibodies
       
  2. Mutations in the APC gene result in:
    a) FAP
    b) AFAP
    c) Lynch Syndrome
    d) a & b
       
  3. Patients with AFAP phenotype have:
    a) alternatively spliced sequence in exon 9
    b) mutations in 5' to codon 168
    c) mutations in 3' to codon 1580
    d) all of the above