Association for Molecular Pathology


Self-Test: AMP Case Report Article in CAP TODAY

Metastatic Cancer of Unknown Primary Origin: Diagnostic Challenges

  1. How can a tumor of unknown primary be identified?
    a) Clinically by typical distribution pattern and location for the primary.
    b) IHC panels.
    c) Imaging studies (CAT scan, MRI, PET).
    d) Endoscopy.
    e) Molecular profiling of a metastasis.
    f) All of the above.
       
  2.

Which of the following statements regarding cancer of unknown primary (CUP) is correct?

    a) CUP comprises about three to five percent of all new cancer diagnoses in the United States.
    b) Median survival from diagnosis is generally only three to four weeks.
    c) The vast majority of CUP are poorly differentiated and undifferentiated carcinomas.
    d) If a primary cannot be identified, the patient does not qualify for chemotherapy.
       
  3.

Molecular tests for the identification of CUP:

    a) May analyze the expression of mRNA or microRNA.
    b) Compare the molecular profile of the “unknown” with the profiles of previously established known tumors.
    c) Can successfully be performed on small biopsies.
    c) All of the above.