Association for Molecular Pathology


Self-Test: AMP Case Report Article in CAP TODAY

Molecular techniques in a case of concurrent BCR-ABL1-positive chronic CML and CMML

 

  1. Which of the following molecular techniques is critical for the diagnosis and minimal residual disease monitoring of CML, BCR-ABL1 positive?
    a) Conventional cytogenetics
    b) Real-time PCR
    c) FISH
    d) PCR-based DNA sequencing
    e) All of the above
       
  2. Which of the following molecular techniques is most commonly utilized to detect ABL1 tyrosine kinase domain point mutations?
    a) Conventional cytogenetics
    b) FISH
    c) Southern blot analysis
    d) PCR-based DNA sequencing
    e) Real-time PCR
       
  3. Molecular testing of which of the following genes is integral to establishing the diagnosis of CMML?
    a) PDFRA
    b) PDGFRB
    c) BCR-ABL1 rearrangement
    d) RAS
    e) All of the above