As a reminder for AMP members, feel free to use the CHAMP community when you have questions for your AMP colleagues regarding bird flu.
Information on Bird Flu (CDC)
CDC Bird Flu Update Feb 2025 (AMA) Additional Videos
What to Know About Bird Flu Handout (CDC)
Influenza (Avian and other zoonotic) Fact Sheet (WHO)
H5N1 Technical Report (CDC)
2020-2024 Highlights and History of Avian Influenza (CDC)
Current Situation Summary (CDC)
Current U.S. Bird Flu Situation in Humans (CDC)
How CDC is Monitoring Influenza Data (CDC)
Updates on Highly Pathogenic Avian Influenza (HPAI) (FDA)
Investigation of Avian Influenza A (H5N1) Virus in Dairy Cattle (FDA)
Infections in Livestock (USDA)
Genomic Tracking (Nextstrain)
United States HPAI Outbreak Tracking (GISAID)
Recent CLIAC Meeting (November 6-7, 2024)
Human
Non-Human
Case Definitions (CDC)
General FAQ for Clinical Laboratories on Testing of HPAI H5N1 (ASM and APHL)
Interim Recommendations for Prevention and Monitoring (CDC)
Recommendations for Investigations and Response (CDC)
Evaluating and Managing Patients (CDC)
HAN: Accelerated Subtyping of Influenza A in Hospitalized Patients (CDC)
Use of Antivirals for Treatment (CDC)
Use of Antivirals Chemoprophylaxis (CDC)
What should Local Health Departments Know About Avian Influenza: A Q&A with CDC (National Association of County and City Health Officials (NACCHO))
Follow-up of Close Contacts of Persons Infected with HPAI (CDC)
Laboratory Biosafety:
Biosafety in Microbiological and Biomedical Laboratories—6th Edition (CDC)
See Pages 262, Highly Pathogenic Avian Influenza (HPAI) A Viruses
Note that HPAI A viruses are CDC/USDA select agents!
See BMBL 6 Appendix F for more information: Biosafety in Microbiological and Biomedical Laboratories—6th Edition (CDC)
Community Health Biosafety:
Infection Control and Safety When Collecting Specimens and Caring for Patients:
CDC Laboratorian Guidance for Specimen Collection and Testing:
Specimen Submission Form (CDC)
Before sending specimens, state and local health departments should contact the CDC Influenza Division Epidemiology and Prevention Branch at (404) 639-3747 Monday – Friday, 8:30 AM – 5:00 PM (or the on-call epidemiologist at (770) 488-7100 at all other times) or flusupport@cdc.gov.
Influenza Specimen Collection (CDC)
Note that CDC recommends collecting a conjunctival swab from patients with conjunctivitis (see here).
Collect both a conjunctival swab and a respiratory specimen (e.g., nasopharyngeal swab) even if the patient doesn’t have respiratory symptoms.
FDA Influenza IVD Tests with FDA 510(K) Clearance, EUA, or de nova request for Humans:
Influenza A/H5N1 Specific Detection Test
Influenza A/H7N9 Specific Detection Test
Influenza A/H1/H1pdm09/H3 Seasonal Subtyping Tests
Influenza A Tests (no subtyping)
Farm worker safety:
American Society for Microbiology Sentinel Level Clinical Laboratory Guidelines
Information relevant to incidental detection of HPAI on routine influenza IVDs and LDTs
Labs are not encouraged to develop or validate specific LDTs for HPAIs at this time.
Labs can contact relevant IVD manufacturers for pan-Influenza A primer/probe coverage information on FDA cleared assays.
Labs that run LDPs for pan-Influenza A detection can refer to published sequences from recent human and bovine cases for primer/probe coverage:
On April 22, 2013, the FDA issued an Emergency Use Authorization (EUA) for the CDC Human Influenza Virus Real-Time RT-PCR Diagnostic Panel-Influenza A/H7 (Eurasian Lineage) Assay. More information is available from the FDA website. Note that issuance of this EUA does NOT indicate that an actual public health emergency exists in the United States. Distribution of diagnostic test kits domestically is a preparedness measure. For information on the latest available FDA H7 molecular assays via EUA, see the FDA website. These EUAs will cease to be effective when the declaration of emergency is terminated under section 564(b)(2) of the Act or when the EUA is revoked under section 564(g) of the Act. (CDC website)
CDC has developed diagnostic test materials to specifically detect the avian influenza A(H7N9) virus that was first identified in China in 2013. Testing with the CDC Human Influenza Virus Real-Time RT-PCR Diagnostic Panel-Influenza A/H7 (Eurasian Lineage) Assay should not be performed unless the patient meets clinical and epidemiologic criteria for testing suspect specimens.